Sensory Gating and Inhibitory Function in Late-life Schizophrenia
نویسندگان
چکیده
منابع مشابه
Neurobiological studies of sensory gating in schizophrenia.
The sensory disturbance in schizophrenia is often described as an inability to filter out extraneous noise from meaningful sensory inputs. The neurobiological basis of this inability to filter has been examined using auditory evoked potentials, which are computerized averages of the brain's electrical response to sound. The sounds are presented in pairs to test the ability of the brain to inhib...
متن کاملSchizophrenia, sensory gating, and nicotinic receptors.
A series of human and animal investigations has suggested that altered expression and function of the alpha7-nicotinic cholinergic receptor may be responsible for the auditory sensory gating deficit characterized in schizophrenia patients and their relatives as diminished suppression of an auditory-evoked response (P50) to repeated stimuli. This finding, in conjunction with evidence for familia...
متن کاملSensory gating deficits and impaired quality of life in patients with schizophrenia: A preliminary study.
BACKGROUND New determinants of quality of life in schizophrenia need to be identified. As sensory gating deficit is core impairment in schizophrenia, the present study hypothesized that sensory gating deficit is a determinant of impaired quality of life in schizophrenia. This study therefore investigated the relationship between sensory gating deficit and quality of life in patients with schizo...
متن کاملLateralization of auditory sensory gating and neuropsychological dysfunction in schizophrenia.
OBJECTIVE Sensory gating assessed via EEG in a paired-click paradigm has often served as a neurophysiological metric of attentional function in schizophrenia. However, the standard EEG measure of sensory gating using the P50 component at electrode Cz does not foster differential assessment of left and right hemisphere contributions. Magnetoencephalography (MEG) is complementary to EEG, and its ...
متن کاملNeuropsychological correlates of P50 sensory gating in patients with schizophrenia.
Impaired inhibition of P50 cerebral evoked response is one of the best validated endophenotypes in schizophrenia. There are controversial data on the relationship between P50 evoked potential deficit and measures of cognitive function in schizophrenia. A comprehensive clinical and neurocognitive assessment plus an evaluation of P50 sensory gating was performed in 160 schizophrenia patients and ...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 1993
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/19.4.733